个人简介
雷锦志，男，1974年出生，博士，教授，博士生导师。主要从事生物数学和计算系统生物学等研究，在癌症演变动力学、干细胞增殖的多尺度建模等领域取得一系列研究成果，提出原创的异质性干细胞增殖过程数学模型框架。主要研究方向为计算数学、计算系统生物学、生物数学。电子邮箱：jzlei@tiangong.edu.cn。
主要教育工作经历
1991—1995 北京航空航天大学 本科，应用数学
1995—1998 北京航空航天大学 硕士，应用数学
1998—2001 北京航空航天大学 博士，一般力学
2001—2003 清华大学数学科学系 博士后
2003—2019 清华大学 助理研究员/副研究员
周培源应用数学研究中心 研究员
2020— 天津工业大学数学科学学院 教授，博士生导师
2004.8—2005.7 美国加州大学 Irvine 分校 访问助理教授
2005.7—2005.12 加拿大McGill University 访问学者
科研项目(主持)
2024.1--2024.12自然科学基金重点项目，题目“癌症耐药复发动力学的数学理论与方法”，193.00万元。
2018.1—2019.12 自然科学基金重大研究计划重点集成项目，题目“干细胞增殖的计算建模及其在癌症演变动力学的应用”，160.00 万元。
2015.1—2017.12 自然科学基金重大研究项目培育项目，题目“成体干细胞再生与分化调控的逆向建模”，70.00万元。
2013.1—2016.12 自然科学基金面上项目，题目“造血系统动力学分析与控制策略研究”，78.00万元.
2007.1—2009.12 自然科学基金青年项目，题目“影响果蝇成虫盘发育的基因 网络的数学模型”，17.00 万元。
学术兼职
工业与应用数学学会数学生命科学专业委员会副主任
运筹学会计算系统生物学分会常务委员
中国生物信息学学会（筹）网络生物学专委会委员
中国数学会生物数学专业委员会委员
Mathematics in Applied Sciences and Engineering 编委
Mathematical Biosciences and Engineering 编委
Zentralblatt MATH 评论员
AMS Math 评论员
科研情况
主要从事数学理论和系统生物学方面的研究，研究方向为动力系统及其应用、计算系统生物学、数学肿瘤学。近年来主要从事计算系统生物学领域的研究，对从分子到多细胞体系不同尺度的生命过程建立可计算模型，以实验事实为基础探索复杂现象背后的普适规律和定量模型，通过数学和计算手段研究生命科学问题。主要研究内容包括：蛋白质折叠的物理机制、发育生物学中模态形成和鲁棒性的机制、造血系统动力学与动态血液病、基因调控网络的动力学、计算癌生物学、生物信息学、健康大数据分析。到目前共发表论文90 余篇，出版了三本系统生物学著作，主持国家自然科学基金项目五项。
专著/译著
1. 雷锦誌，系统生物学—建模、分析、模拟，上海科学技术出版社，2010.
2. 刘俊丽，武林晓，雷锦誌，英语科技写作，机械工业出版社，2011.
3. Jinzhi Lei， Systems Biology-Modeling, Analysis, and Simulation, Springer, Switzerland. 2021.
4. 李晓文，武林晓，雷锦志(翻译)，英语科技写作(第二版)，世界图书出版公司，2023.
5. 雷锦志，易鸣，杨凌，刘锐，祁宏，系统生物学，科学出版社，2024.
发表论文
[98]Lai, X., Jiao, X., Zhang, H., Lei, J.*, 2024, Computational modeling reveals key factors driving treatment-free remission in chronic myeloid leukemic patients. npj Systems Biology and Applications, 10:45.
[97] Jiang, H., Liu, J. X., Song, Y., Lei, J.*, 2024. Quantitative modeling of stemness in single-cell RNA sequencing data: a nonlinear one-class support vector machine method. 31(1): 1-17.
[96] Huang, R., Situ, Q., Lei, J.*, 2024. Dynamics of cell-type transition mediated by epigenetic modifications, J Theor Biol, 577:111664.
[95] Liang, X., Lei, J.*, 2024. Oscillatory dynamics of heterogeneous stem cell regeneration. Communications on Applied Mathematics and Computation. 6:431-453.
[94] Pei, Y.*, Han, S., Li, C., Lei, J., Wen, F., 2023. Data-based modeling of breast cancer and optimal therapy. J Theor Biol, 573:111593.
[93] Zhang, H., Zhang, M., Lei, J.*, 2023. A mathematical model with aberrant growth correction in tissue homeostasis and tumor cell growth. J Math Biol, 86:2.
[92] Wu, F., Liang, X., Lei, J.*, 2023. Modelling COVID-19 epidemic with confirmed cases-driven contact tracing quarantine. Infectious Disease Modelling, 8:415-426.
[91] Xue, L., Zhang, H., Zheng, X., Sun, W., Lei, J.*, 2023. Treatment of melanoma with dendritic cell vaccines and immune checkpoint inhibitors: A mathematical modeling study. J Theor Biol, 568:111489.
[90] Ma, S., Lei, J., Lai, X.*, 2023. Modeling tumour heterogeneity of PD-L1 expression in tumour progression and adaptive therapy. J Math Biol, 86:38.
[89] Zhang, H., Lei, J.*, 2022. Optimal treatment strategy of cancers with intratumor heterogeneity. Math Biosci Eng, 19(12):13337-13373.
[88] Lv, Q., Ma, W., Lei, J.*, 2022. Power law dependence in a random differential equation. Int J Mod Phys B, 37(4):2350040.
[87] Wang, S., Hao, M., Pan, Z., Lei, J.*, Zou X.*, 2021. Data-driven multiscale mathematical modeling of SARS-CoV-2 infection reveals heterogeneity among COVID-19 patients. PLoS Comput Biol, 17(11):e1009587.
[86] Deng, Y., Xing, S., Zhu, M., Lei, J.*, 2021. Impact of insufficient detection in COVID-19 outbreaks. Math Biosci Eng, 18(6):9727-9742.
[85] Liu, C., Hao, L., Lei, J.*, 2021. Macroscopic dynamics of gene regulatory networks revealed by individual entropy. Int J Mod Phys B. 35(2), 2150331.
[84] Xu, C., Pei, Y. -Z., Liu, S. -Q., Lei, J.*, 2021. Effectiveness of non-pharmaceutical interventions against local transmission of COVID-19: An individual-based modelling study. Infectious Disease Modelling, 6:848-858.
[83] Chang, C., Shao, C., Jiao, X., Bai, Y., Li, M., Shi, H., Lei, J.*, Zhong, X.*, 2021. Individual cell-based modeling of tumor cell plasticity-induced immune escape after CAR-T therapy. Comput Syst Oncol, 1:e21029.
[82] Yu, Y. -S., Yang, Z. -Q., Lei, J.*, 2020. Using single-cell entropy to describe the dynamics of reprogramming and differentiation of induced pluripotent stem cells. Int J Mod Phys B, 34(30): 2050288.
[81] Lei, J., 2020. Viewpoints on modelling: comments on ``Achilles and the torroies: some cavets to mathematical modelling in biology'', Math Appl Sci Eng, 1(1), 1-7.
[80] Liu, J. -X., Song, Y., Lei, J.*, 2020. Singel-cell entropy to quantify the cellular order parameter from single-cell RNA-seq data. Biophys Rev Lett, 15(1):35-49, doi:10.1142/S1793048020500010.
[79] Lei, J., 2020. Evolutionary dynamics of cancer: From epigenetic regulation to cell population dynamics--mathematical framework, application, and open problems. Sci China Math, 63(3), 411-424.
[78] Lei, J., 2020. A general mathematical framework for understanding the behavior of heterogeneous stem cell regeneration. J Theor Biol, 492, 110196.
[77] Zhuge, C., Mackey, M., Lei, J.∗, 2019. Origins of oscillation patterns in cyclical thrombocytopenia. J. Theor. Biol, 462, 432-445.
[76] Yang, H. L., Lei, J.*, 2019. A mathematical model of chromosome recombination-induced drug resistance in cancer therapy. Math Biosci Eng., 16(6), 7098-7111.
[75] Huang, R. -S, Lei, J.*, 2019. Cell-type switches induced by stochastic histone modification inheritance. Discrete and Continuous Dynamical Systems -B, 22(11), 1-19.
[74] Ye, Y. -S., Yang, Z. -Q., Lei, J.*, 2019. Stochastic telomere shortening and the route to limitless replicative potential. J. Comput. Biol., 26, doi:10.1089/cmb.2018.0234.
[73] Zhuge, C., Mackey, M., Lei, J.*, 2019. Origins of oscillation patterns in cyclical thrombocytopenia. J. Theor. Biol, 462, 432-445.
[72] Yu, Y., Situ, Q., Jia, W., Li, J., Wu, Q.∗, Lei, J.∗, 2018. Data driven mathematical modelling reveals the dynamic mechanism of MSC-induced neovascularization. The FASEB Journal, fj.201801652R (2018). doi:10.1096/fj.201801652R.
[71] Jiao, X., Lei, J.∗, 2018. Dynamics of gene expression based on epigenetic modifications. Communications in Information and Systems, 18, 125148.
[70] Hao, L., Yang, Z., Lei, J.∗, 2018. Underlying mechanisms of cooperativity, input specificity, and associativity of long-term potentiation through a positive feedback of local protein synthesis. Frontiers in Computational Neuroscience, 12, 25.
[69] Song, Y., Situ, F., Zhu, H., Lei, J.∗, 2018. To be the Prince to wake up Sleeping Beauty: the rediscovery of the delayed recognition studies. Scientometrics, 117, 9-24.
[68] Huang, R., Lei, J.∗, 2018. Dynamics of gene expression with positive feedback to histone modifications at bivalent domains. Int. J. Mod. Phys. B, 32, 1850075.
[67] Hao, L., Yang, Z., Gong, P., Lei, J.∗, 2018. Maintenance of postsynaptic neuronal excitability by a positive feedback loop of postsynaptic BDNF expression. Congitive Neurodynamics, 12(4), 403-416, doi:10.1007/s11571- 018-9479-z.
[66] Lei, J., Chen, D. B.∗, Nie, Q.∗, 2018. A single-cell epigenetic model for parental psychological stress-induced transgenerational reprogramming in offspring. Biology of Reproduction, 96(6), 846-855, doi:10.1093/biolre/ioy050.
[65] Shi, B., Guo, X., Yang, Y., Xiong, Y., Wang, J., Hayahshi, K., Lei, J., Zhang, L.∗, Jiao, Y.∗, 2018. Feedback from lateral organs controls shoot apical meristem growth by modulating auxin transport. Dev. Cell, 44(2), 204-216.
[64] Xia, W., Lei, J.∗, 2018. Formulation of the protein synthesis rate with sequence information. Math. Biosci. Eng., 15(2), 507-522.
[63] Song, S., Ren, H., Lei, J.∗, 2017, Collaborations between CpG sites in DNA methylation. Int. J. Mod. Phys. B. 31, 1750243.
[62] Situ, Q., Lei, J.∗, 2017. A mathematical model of stem cell regeneration with epigenetic state transitions. Mathematical Biosciences and Engineering. 14(5-6), 1379-1397.
[61] Guo, Y., Nie, Q., MacLean, A.L., Li, Y., Lei, J.*, Li, S.*, 2017. Multiscale modeling of inflammation-induced tumorigenesis reveals competing oncogenic and oncoprotective roles for inflammation. Cancer Research, 77, 6429-6441.
[60] Li, J., Du, M-M., Wang, R., Lei, J.∗, Wu, Y.∗, 2016. Astrocytic gliotransmitter: diffusion dynamics and induction of information processing on tripartite synapses. Int. J. Bif. Chaos, 26, 1650138.
[59] Lei, J., Lo, W-C., Nie, Q.*, 2016. Mathematical models of morphogen dynamics and growth control, Annals of Mathematical Sciences and Applications, 1, 427-471.
[58] Lei, J., Lo, W-C., Nie, Q., 2016. Mathematical models of morphogen dynamics growth control. Ann. Math. Sci. Appl., 1, 427-471.
[57] Wang, R., Li, J., Du, M., Lei, J.∗, Wu, Y.∗, 2016. Transition of spatiotemporal patterns in neuronal networks with chemical synapses. Commun. Nonlinear Sci. Numer. Simulat., 40, 80-88.
[56] Jin, H., Lei, J.∗, 2016. A hybrid model of molecular regulation and population dynamics for yeast autophagy. J. Theor. Biol., 402, 45-53.
[55] Zhuge, C., Sun, X., Chen, Y., Lei, J.∗, 2016. PDCD5 interacts with p53 and functions as a regulator of p53 dynamics in the DNA damage response. J Theor. Biol. 388, 1-10.
[54] Lei, J., 2016. On a classification of polynomial differential operators with respect to the type of first integrals. J Differential Equations, 260, 1993-2025.
[53] Lei, J., 2015. The modeling and analysis of biochemical reaction systems. J Jianxi Normal Univ. 2015(03):230-239.
[52] Xie, J., Xiang, C., Ma, J., Tan, J., Wen, T., Lei, J., Nie, Q.∗, 2015. An adaptive hybrid algorithm for global network alignment. Computational Biology and Bioinformatics, IEEE/ACM Transcations. vol. PP, no. 99, pp. 1. doi:10.1109-TCBB.2015.2465957.
[51] Bi, Y., Yang, Z., Zhuge, C., Lei, J.∗, 2015. Bifurcation analysis and potential landscape of the p53-Mdm2 oscillator regulated by the co-activator programmed cell death 5. Chaos, 25, 113103.
[50] Hao, L., Yang, Z., Lei, J.∗, 2015. Bifurcation analysis of a delay differential equation model associated with the induction of long-term memory. Chaos, Solitons and Fractals, 81, 162-171.
[49] Ma, S., Zhu, K., Lei, J.∗, 2015. Bistability and state transition of a delay differential equation model of neutrophil dynamics. International Journal of Bifurcation and Chaos, 25, 1550017.
[48] Zhang, X., Jin, H., Yang, Z., Lei, J.∗, 2014. Effects of elongation delay in transcription dynamics. Journal of Mathematical Biosciences and Engineering, 11, 1431-1448.
[47] Wang, Z., Li X., Lei, J.*, 2014. Moment boundedness of linear stochastic delay differential equations with distributed delay. Stochastic Processes and their Applications, 124, 586-612.
[46] Lei, J., Levin, S.A.*, Nie, Q., 2014. Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation, PNAS, E880-E887.
[45] Jin, H., Lei, J.∗, 2014. A mathematical model of cell population dynamics with autophagy response to starvation. Mathematical Bioscience, 258, 1- 10.
[44] Wang, Z., Li, X., Lei, J.∗, 2014. Moment boundedness of linear stochastic delay differential equation. Discrete and Continuous Dynamics System-B, 19, 2963-2991.
[43] Jin, H., Lei, J.∗, 2014, Modeling stochastic biochemical reaction with deterministic delay differential equations. Mathematical Modelling of Natural Phenomena, 9, 79-91.
[42] Yvinec, R., Zhuge, C., Lei, J., Mackey, M., 2014. Adiabatic reduction of a model of stochastic gene expression with jump Markov process, J. Math. Biol., 68, 1051-1070.
[41] Zhuge, C., Sun, X., Lei, J.∗, 2013. On positive solutions and the Omega limit set for a class of delay differential equations. Discrete and Continuous Dynamics System-B, 18, 2487-2503.
[40] Lei, J., Wang, D., Song, Y., Nie, Q., Wan, F.∗, 2013. Robustness of morphogen gradients with “bucket brigade” transport through membrane- associated non-receptors. Discrete and Continuous Dynamics System-B, 18, 721-739.
[39] Brooks, G., Langlois, G., Lei, J.∗, Mackey, M., 2012. Neutrophil dynamics after chemotherapy and G-CSF: The role of pharmacokinetics in shaping the response. J. Theor. Biol. 315, 97-109.
[38] Lei, J., 2012. Recent progress in hematological dynamics. Advances in Mechanics, 42, 294-313.
[37] Naqib, F., Quail, T., Musa, L., Vulpe, H., Nadeau, J., Lei, J., Glass, L.∗, 2012. Tunable oscillations and chaotic dynamics in systems with localized synthesis. Phys. Rev. E, 84, 046210.
[36] Bernard, S., Pujo-Menjouet, L., Colijn, C., Lei, J., Mackey, M.C.∗, 2012. Mathematical modeling of hematopoiesis. UNECO Encyclopedia of Life Support Systems (In press).
[35] Zhuge, C., Lei, J.∗, Mackey, M.C., 2012. Neutrophil dynamics in response to chemotherapy and G-CSF. J. Theor. Biol., 293, 111-120.
[34] Zhuge, C., Chang, Y., Li, Y., Chen, Y., Lei, J., 2011. PDCD5-regulated cell fate decision after UV-irradiation induced DNA damage. Biophys. J., 101, 2582-2591.
[33] Lei, J.∗, Mackey, M.C., 2011. Deterministic Brownian motion generated from differential delay equations. Phys. Rev. E., 84, 041105.
[32] Hong, L.∗, Lei, J., 2011. A general shape equation for local regular structure of bimolecular chains. 2011 IEEE International Conference on Systems Biology, ISB 2011, 144-148.
[31] Sun, X.∗, Lei, J., Perc, M., Kurths, J., Chen, G., 2011. Burst synchronization transitions in a neuronal network of subnetworks. Chaos, 21, 016110.
[30] Gu, C., Zhang, J., Chen, Y., Lei, J.∗, 2011. A trigger model of TNF signaling induced apoptosis. BMS Systems Biology, 5 (Suppl 1):S13, doi:10.1186/1752- 0509-5-S1-S13.
[29] Chu, J.∗, Lei, J.∗, Zhang, M.∗, 2011. Lyapunov stability for conservative systems with lower degrees of freedom. Discrete and Continuous Dynamics System-B, 16, 423-443.
[28] Lei, J., 2012. Stochastic modeling in system biology. J. Adv. Math. Appl.,1, 76-88. arXiv:1104:4524.
[27] Lei, J., Wan, F., Lander, A., Nie, Q.∗, 2011, Robustness of signaling gradient in drosophila wing imaginal disc. Discrete and Continuous Dynamics System-B, 16, 835-866.
[26] Lei, J., Systems Biology–Modeling, Analysis, Simulation. Shanghai Scientific Press, Shanghai, 2010.
[25] Sun, X.∗, Lei, J., Perc, M., Lu, Q., Lv, S., 2010. Effects of channels noise on firing coherence of small-world Hodgkin-Huxley neuronal networks. Eur. Phys. J. B, 79, 61-66.
[24] Lei, J.∗, Huang, K., 2010. Protein Folding: A perspective from statistical physics. In Protein Folding, Eric C. Walters ed., NOVA Publishers, 2010, pp. 579-604.
[23] Gu, C., Zhang, J., Chen, Y., Lei, J.∗, 2010. A mathematical model of Fas signaling induced apoptosis. The 4th International Conference on Computational Systems Biology.
[22] Lei, J.∗, Mackey, M., 2010. Multistability in an age-structured model of hematopoiesis: Cyclical neutropenia, J. Theor. Biol. 270, 143-153.
[21] Ma, S., Wang, X., Lei, J., Feng, Z.∗, 2010. Dynamics of the delay hematological cell model. Inter. J. Biomathematics. 3, 105-125.
[20] Lei, J.∗, 2010. Probability distribution of the radius of gyration of freely jointed chains. J. Chem. Phys. 133, 104903.
[19] Lei, J., 2010. Mathematical model of the Dpp gradient formation in Drosophila wing imaginal disc (in Chinese). Chinese Science Bulletin. 55, 984-991.
[18] Lei, J.∗, Song, Y., 2010. Mathematical model of the formation of morphogen gradients through membrane-associated non-receptors. Bull. Math. Biol. 72, 805-829.
[17] Lei, J.∗, Huang, K., 2009. Elastic energy of proteins and the stages of protein folding. Europhys. Lett. 88, 68004.
[16] Lei, J., He, G., Liu, H., Nie, Q.∗, 2009. A delay model for noise-induced bi-directional switching. Nonlinearity 22, 2845-2859.
[15] Chu, J., Lei, J., Zhang, M.∗, 2009. The stability of the equilibrium of a nonlinear planar system and application to the relativistic oscillator. J. Diff. Equs. 247, 530-542.
[14] Hong, L.∗Lei, J.∗, 2009. Scaling law for the radius of gyration of proteins and its dependence on hydrophobicity. J. Polym. Sci. B: Polym. Phys. 47, 207-214.
[13] Lei, J., 2009. Stochasticity in single gene expression with both intrinsic and extrinsic noise and fluctuation in kinetic parameters. J. Theor. Biol. 256, 485-492.
[12] Hong, L.∗Lei, J.∗, 2008. Statistical mechanical model for helix-sheet-coil transitions in homopolypeptides. Phys. Rev. E 78, 051904.
[11] Lei, J.∗, Huang, K., 2008. Dynamics of Alpha-Helix formation in the CSAW model. Euro. Phys. J. E. 27, 197-204.
[10] Lei, J.∗, Mackey, M.C.∗, 2007. Stochastic differential delay equation: Moment stability and its application to the hamatopoietic stem cell regulation system. SIAM. J. Appl. Math. 67(2007), 387-407.
[9] Lemaire, V., Lee, C.F. Lei, J., Metivier, R., Glass, L., 2006. Sequential recruitment and combinational assembling of multiprotein complexes in transcriptional activation. Phys. Rev. Lett. 96(19), 198102.
[8] Lei, J., Santoprete, M.∗, 2006. Rosette Central Configurations, Degenerate Central Configurations and Bifurcation. Celestial Mechanics and Dynamical Astronomy 94, 271-287.
[7] Lemaire, V., Lee, C-F., Lei, J., Metivier R., Glass L.*, 2006. Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation, PRL, 96, 198102.
[6] Lei, J., Torres, P.J.∗, 2006. L1 criteria for stability of periodic solutions of a newtonian equation. Math. Proc. Cambridge Philos. Soc. 140-2, 359-368.
[5] Lei, J.∗, Yang, L., 2005. Algebraic multiplicity and the Poincare problem. In Differential equations with symbolic computation, Wang Dong- ming, Zheng Zhiming (Eds), Chapter 9, Birkauser.
[4] Lei, J., Torres, P.J., Zhang, M.∗, 2005. Twist Character of the Fourth Order Resonant Periodic Solution. J. Dynam. Diff. Eqs. 17(1), 21-50.
[3] Lei, J.∗, Li, X., 2003. Some dynamical properties of the stadium billiard. Physica D: Nonlinear Phenomena 189(1-2), 49-60.
[2] Lei, J., Li, X., Yan, P., Zhang, M.∗, 2003. Twist character of the least amplitude periodic solution of the forced pendulum. SIAM J. Math. Anal.35, 844-867.
[1] Lei, J., Zhang, M.∗, 2002. Twist property of periodic motion of an atom near a charged wire. Lett. Math. Phys. 60(1), 9-17.